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本片讲述了洛杉矶警察局巡逻老将雷·曼德尔和新警察尼克·霍兰德在追捕两名逍遥法外的警察杀手时度过的一个难忘的夜晚。 随着两名警察杀手逍遥法外，并在寻找更多的目标，曼德尔和霍兰德必须在一座即将沸腾的城市中战斗，还要面对杰克·凡赞特，一名精神失常的流氓警察，此时在他们的巡逻区内疯狂地报复。随着夜幕的降临，曼德尔和霍兰德开着警车在洛杉矶危险的街道上徘徊，只有几层薄薄的金属和玻璃保护着他，他们在与时间赛跑，寻找失踪的女孩。 这对搭档在抓坏蛋方面毫无固定章法，当他们遇到两个以杀警察为乐的连环杀手时，一出“互相被对方蠢哭”的戏码就要上演。

Sometime in the near future, paraplegic prison inmate Matt Mills meets "The Board" of Satoshi-Telefair Industries, who thank him for joining the Program. Under pressure and with a promise to make him walk again, Mills agrees to volunteer. He is injected with a synthetic nanomaterial and suffocated, only to wake up with restored use of his legs, yet alone in a steel cell in the first spoke of an experimental apparatus - The Wheel. A series of assailants inflict a multitude of damage to Mills' body and torment his mind, yet the synthetic nanomaterial not only restores his damaged organs, it re-engineers his strength. The experiment might be designed to kill, but Mills is determined to survive - and get back to his daughter before The Board finds her first.